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A Dermatologist informs us.
Doctor Guy Battaglino
Dermatology & Cosmetic Medicine
Lugano, Switzerland
Cutaneous ageing is due to physical agents like solar radiation, and climatic factors…as well as to internal factors related to the natural senescence of cutaneous tissue.
It appears through the atrophy of the skin and a qualitative and quantitative deterioration of derm.
DERM:
It has two principal components:
- The fundamental substance, glycosaminoglycans (structural glycoproteins) from which the most significant are hyaluronic acid, chondroïtine and chrondroïtine-sulphate.
- Fibrous proteins: collagen gives the skin its resistance, Elastin (elastic fibers) ensures its elasticity and tonicity.
These two elements are produced by the fibroblasts, cells largely represented in the skin.
ALTERATIONS OF DERM DUE TO AGEING:
Apart from the pathological states (arteriosclerosis, diabetes), age leads to a rarefaction, then a disappearance of elastic fibres.
For elastin, reduction and deterioration (fragmentation) of fibres appears. All that leads to the appearance of lines ( 'heliodermy' ) and more marked and durable wrinkles, dependent on a drop in tonicity and cutaneous elasticity ( 'chronodermy' ).
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KappaElastin™E:
Lack or absence of elastin in the derm can be compensated by external contribution. Elastin is obtained from natural tissue. Elastin is a non soluble molecule with a very high molecular weight.
Its controlled hydrolysis in smaller fragments (peptides) reconstitutes the soluble molecule Elastin and allows it to regenerate our level of elastin.
However, if its fragmentation is too excessive, the resulting product looses the elasticity of our original elastin molecules.
This original and effective process is made possible only by SOLUBLE KappaElastin™ or Elastin bio-peptides.
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As shown in scientific research, its partial hydrolysis allows the transepidermic passage and the progressive reconstitution of a “YOUTH CAPITAL'' by fixing itself among our aging elastin fibers. Its presence also stimulates the fibroblasts for the endogenous production of elastin and neocollagen.
In conclusion, we can say that the discovery of KappaElastin™ represents a real progress in medical cosmetics because it applies a complementary process to the rejuvenation of skin in a soft and progressive form, appreciated by the patients.
Doctor Guy Battaglino
Dermatology & Cosmetic Medicine
Lugano, Switzerland
PRINCIPAL REFERENCE:
U.S. National Library of Medicine
PHARMACOLOGICAL STUDIES OF ELASTIN PEPTIDES (KappaElastin™)
Blood Clearance, percutaneous penetration and tissue distribution.
MENASCHE M, MP JACOB, (1)
G. GODEAU (2), A.M ROBERT (2), L. ROBERT (2), Biol, 1981, 29, n°9, 548-554
1) INSERM U 86, Foundation A. of Rothschild, 29 rue Manin, 75019 PARIS (FRANCE)
2) Laboratoire de Biochimie du Tissu conjonctif (GR CNRS N° 40), Faculté de Médecine, Université Paris-Val de Marne, 8 rue du Général Sarrail, 94010 CRETEIL Cedex (France)
SUMMARY:
The soluble Elastin Peptides obtained by partial hydrolysis of ligament (KappaElastin™) were marked in vitro. Marked KappaElastin™ was managed by intravenous and percutaneous way, its elimination and its distribution in the body given. KappaElastin™ is quickly eliminated primarily by the kidneys. The Elastin Peptides managed by percutaneous way shows that its resorption though the skin takes place.
Histochemical studies made on the skin over a four week period showed an increase in the material taking the coloring of elastin. These histochemical results confirm the increase of elastin peptides in the skin, their association with collagen fibers and also their action on our skin cellular activity.
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